ABSTRACT
Macro- and micromorphological study of Lagenaria siceraria [Molina] Standl., was carried out with the aim off finding out the characteristic features of the different organs of the plant in both entire and powdered forms
Subject(s)
Cucurbitaceae/anatomy & histology , Plant Structures , Flowers/ultrastructure , Plant Roots/ultrastructure , Plant Leaves/ultrastructure , Fruit/ultrastructureABSTRACT
Following a bioassay-guided approach four bromopyrrole alkaloids, oroidin [1], 4,5-dibromopyrrole-2-carboxanijde [2], 4,5-dibromopyrrole-2-carboxylic acid [3] and 4,5-dibromopyrrole-2-[N methoxymethyl] carboxamide [4], were isolated from the bioactive ethyl acetate extract of the tropical marine sponge Agelas oroides. The structures of the isolated compounds were elucidated using their UV, NMR [I D and II D] and mass spectra. Fish feeding, brine shrimp, cytotoxic activity against L5178Y and Hela cell lines, protein kinase inhibition test and the antimicrobial activities for the isolated compounds were investigated. The fish-feeding assay showed that the total alcoholic extract was highly active and the major compound, oroidin, is responsible for this activity [in concentration of 80 mg/10 ml]